KLF4‑mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP

KLF4‑mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP

The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of NKG2D ligands (NKG2D-L), including MICA. The absence of NK...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Alkhayer, Reem, Ponath, Vivane, Frech, Miriam, Adhikary, Till, Graumann, Johannes, Neubauer, Andreas, Pogge von Strandmann, Elke
Формат: Статья
Язык:английский
Опубликовано: Philipps-Universität Marburg 2023
Предметы:
Immune evasion
Natural killer cells
APTO253
Medizin
Immunotherapy
NKG2D/NKG2D-ligand axis
Medical sciences Medicine
Online-ссылка:PDF-полный текст
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!
Publikationen im Open Access gefördert durch die UB

Схожие документы