First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B

First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B

Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is the most common congenital malformation of the upper digestive tract. This study represents the first genome-wide association study (GWAS) to identify risk loci for EA/TEF. We used a European case-control sample comprising 764...

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Autoren: Gehlen, Jan, Giel, Ann-Sophie, Köllges, Ricarda, Bornholdt, Dorothea, Jung, Daphne, Hoyer, Paul D., Nordenskjöld, Agneta, Hess, Timo, Baumgarten, Martig, Seitz, Guido, Schumacher, Johannes
Beteiligte: et. al.
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2022
Schlagworte:
genome-wide association study (GWAS)
FOXF1/FOXC2/FOXL1
HNF1B
CTNNA3
multifactorial diseases
esophageal atresia (EA)
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Signatur: urn:nbn:de:hebis:04-es2024-07697
Publikationsdatum: 2024-01-22
Quelle: Erstveröffentlichung: Gehlen J, Giel AS, Köllges R, Haas SL, Zhang R, et. al. First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B. HGG Adv. 2022 Jan 25;3(2):100093. https://doi.org/10.1016/j.xhgg.2022.100093
Downloads: 34 (2024)
Lizenz: https://creativecommons.org/licenses/by-nc-nd/4.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/es/2024/0769
https://doi.org/10.1016/j.xhgg.2022.100093

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