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NMOSD IgG Impact Retinal Cells in Murine Retinal Explants
Neuromyelitis optica spectrum disorders (NMOSD) are chronic inflammatory diseases of the central nervous system, characterized by autoantibodies against aquaporin-4. The symptoms primarily involve severe optic neuritis and longitudinally extensive transverse myelitis. Although the disease progres...
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| Autors principals: | , , , , , , |
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| Format: | Article |
| Idioma: | anglès |
| Publicat: |
Philipps-Universität Marburg
2023
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| Accés en línia: | PDF a text complet |
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| Sumari: | Neuromyelitis optica spectrum disorders (NMOSD) are chronic inflammatory diseases of
the central nervous system, characterized by autoantibodies against aquaporin-4. The symptoms
primarily involve severe optic neuritis and longitudinally extensive transverse myelitis. Although
the disease progression is typically relapse-dependent, recent studies revealed retinal neuroaxonal
degeneration unrelated to relapse activity, potentially due to anti-aquaporin-4-positive antibodies
interacting with retinal glial cells such as Müller cells. In this exploratory study, we analysed the
response of mouse retinal explants to NMOSD immunoglobulins (IgG). Mouse retinal explants were
treated with purified IgG from patient or control sera for one and three days. We characterized tissue
response patterns through morphological changes, chemokine secretion, and complement expression.
Mouse retinal explants exhibited a basic proinflammatory response ex vivo, modified by IgG addition.
NMOSD IgG, unlike control IgG, increased gliosis and decreased chemokine release (CCL2, CCL3,
CCL4, and CXCL-10). Complement component expression by retinal cells remained unaltered by
either IgG fraction. We conclude that human NMOSD IgG can possibly bind in the mouse retina,
altering the local cellular environment. This intraretinal stress may contribute to retinal degeneration
independent of relapse activity in NMOSD, suggesting a primary retinopathy. |
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| Descripció de l’ítem: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.3390/cimb45090463 |