Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats

Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats

CACNA1C encodes the pore-forming α1C subunit of the L-type Ca2+ channel, Cav1.2. Mutations and polymorphisms of the gene are associated with neuropsychiatric and cardiac disease. Haploinsufficient Cacna1c+/− rats represent a recently developed model with a behavioral phenotype, but its cardiac pheno...

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Autori principali: Fender, Hauke, Walter, Kim, Kiper, Aytug K., Plačkić, Jelena, Kisko, Theresa M., Braun, Moria D., Scharting, Rainer K. W., Rohrbach, Susanne, Wöhr, Markus, Decher, Niels, Kockskämper, Jens
Natura: Articolo
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2023
Soggetti:
CACNA1C
cardiomyocyte
Biowissenschaften, Biologie
remodeling
calcium handling
Life sciences
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