Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

Background: Lassa virus (LASV) can cause severe acute systemic infection in humans. No approved antiviral drugs or vaccines are currently available. Antibody-based therapeutics are considered a promising treatment strategy in the management of LASV disease. Methods: We used chimeric Ifnar?/? C57B...

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Autori principali: Oestereich, Lisa, Müller-Kräuter, Helena, Pallasch, Elisa, Strecker, Thomas
Natura: Articolo
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2023
Soggetti:
arenavirus
virus-like particle
Lassa fever
Medizin
neutralizing antibodies; in vivo protection
Lassa mammarenavirus
Medical sciences Medicine
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