Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

Background: Lassa virus (LASV) can cause severe acute systemic infection in humans. No approved antiviral drugs or vaccines are currently available. Antibody-based therapeutics are considered a promising treatment strategy in the management of LASV disease. Methods: We used chimeric Ifnar?/? C57B...

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Autoren: Oestereich, Lisa, Müller-Kräuter, Helena, Pallasch, Elisa, Strecker, Thomas
Formato: Artigo
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2023
Assuntos:
arenavirus
virus-like particle
Lassa fever
Medizin
neutralizing antibodies; in vivo protection
Lassa mammarenavirus
Medical sciences Medicine
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Área/Cota: urn:nbn:de:hebis:04-es2024-04459
Publikationsdatum: 2024-01-18
Fonte: Erstveröffentlichung: Oestereich, L.; Müller-Kräuter, H.; Pallasch, E.; Strecker, T. Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection. Viruses 2023, 15, 1436. https://doi.org/10.3390/v15071436
Downloads: 20 (2024)
Lizenz: https://creativecommons.org/licenses/by/4.0
Zugangs-URL: https://archiv.ub.uni-marburg.de/es/2024/0445
https://doi.org/10.3390/v15071436

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