AI-based multi-PRS models outperform classical single-PRS models

AI-based multi-PRS models outperform classical single-PRS models

Polygenic risk scores (PRS) calculate the risk for a specific disease based on the weighted sum of associated alleles from different genetic loci in the germline estimated by regression models. Recent advances in genetics made it possible to create polygenic predictors of complex human traits, in...

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Autores principales: Klau, Jan Henric, Maj, Carlo, Klinkhammer, Hannah, Krawitz, Peter M., Mayr, Andreas, Hillmer, Axel M., Schumacher, Johannes, Heider, Dominik
Formato: Artículo
Lenguaje:inglés
Publicado: Philipps-Universität Marburg 2023
Materias:
deep learning
machine learning
regression
breast cancer
Technik
polygenic risk score
Technology (Applied sciences)
Acceso en línea:Texto Completo PDF
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