AI-based multi-PRS models outperform classical single-PRS models

AI-based multi-PRS models outperform classical single-PRS models

Polygenic risk scores (PRS) calculate the risk for a specific disease based on the weighted sum of associated alleles from different genetic loci in the germline estimated by regression models. Recent advances in genetics made it possible to create polygenic predictors of complex human traits, in...

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Detalhes bibliográficos
Principais autores: Klau, Jan Henric, Maj, Carlo, Klinkhammer, Hannah, Krawitz, Peter M., Mayr, Andreas, Hillmer, Axel M., Schumacher, Johannes, Heider, Dominik
Formato: Artigo
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2023
Assuntos:
deep learning
machine learning
regression
breast cancer
Technik
polygenic risk score
Technology (Applied sciences)
Acesso em linha:Texto Completo em Formato PDF
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