Bacterial vesicles block viral replication in macrophages via TLR4‑TRIF‑axis

Bacterial vesicles block viral replication in macrophages via TLR4‑TRIF‑axis

Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transported PAMPs. As important resident immune cells, alveolar macrophages are located at the ai...

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Huvudupphovsmän: Bierwagen, Jeff, Wiegand, Marie, Laakmann, Katrin, Danov, Olga, Limburg, Hannah, Herbel, Stefanie Muriel, Heimerl, Thomas, Dorna, Jens, Jonigk, Danny, Preußer, Christian, Bertrams, Wilhelm, Braun, Armin, Sewald, Katherina, Schulte, Leon N., Bauer, Stefan, Pogge von Strandmann, Elke, Böttcher-Friebertshäuser, Eva, Schmeck, Bernd, Jung, Anna Lena
Materialtyp: Artikel
Språk:engelska
Publicerad: Philipps-Universität Marburg 2023
Ämnen:
Antiviral innate immunity
Outer membrane vesicles
Extracellular vesicles
Pneumonia
Macrophage, Alveolar epithelial cell
Bacterial and viral co-infection
Medizin
Medical sciences Medicine
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