Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis

Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis

Activation of the alternative pathway (AP) of complement is involved in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), although the underlying molecular mechanisms are unclear. To gain insight into the role of the AP, common gene variants in CFH/CFHR1-5,...

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Bibliographische Detailangaben
Autoren: Lucientes-Continente, Laura, Fernández-Juárez, Gema, Márquez-Tirado, Bárbara, Jímenez-Villegas, Laura, Acevedo, Marcedes, Cavero, Teresa, Sánchez Cámara, Luís, Draibe, Juliana, Anton-Pampols, Paula, Carava-Fontán, Fernando, Praga, Manuel, Villacorta, Javier, Goicoechea de Jorge, Elena
Körperschaft: Kidney International (Herausgebendes Organ)
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2023
Schlagworte:
ANCA-vasculitis
complement
Medizin
FHRs
alternative pathway
FH
Medical sciences Medicine
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