Effects of Monoamino-Oxidase-A (MAO-A) Inhibition on Skeletal Muscle Inflammation and Wasting through Pancreatic Ductal Adenocarcinoma in Triple Transgenic Mice

Effects of Monoamino-Oxidase-A (MAO-A) Inhibition on Skeletal Muscle Inflammation and Wasting through Pancreatic Ductal Adenocarcinoma in Triple Transgenic Mice

Cancer cachexia describes a syndrome of muscle wasting and lipolysis that is still largely untreatable and negatively impacts prognosis, mobility, and healthcare costs. Since upregulation of skeletal muscle monoamine-oxidase-A (MAO-A), a source of reactive oxygen species, may contribute to cachexia,...

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Autors principals: Schmich, Simon K. P., Keck, Jan, Bonaterra, Gabriel A., Bertoune, Mirjam, Adam, Anna, Wilhelm, Beate, Slater, Emily P., Schwarzbach, Hans, Fendrich, Volker, Kinscherf, Ralf, Hildebrandt, Wulf
Format: Article
Idioma:anglès
Publicat: Philipps-Universität Marburg 2023
Matèries:
harmine
E3-ligases
pancreatic cancer
cytokines
cachexia
Medizin
KPC model
skeletal muscle atrophy
Medical sciences Medicine
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