Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Background: In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeline as in patients. However, the long and variable, ortho...

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Autores principales: Merle, Nastasja, Elmshäuser, Sabrina, Strassheimer, Florian, Wanzel, Michael, König, Alexander M., Funk, Julianne, Neumann, Michelle, Kochhan, Katharina, Helmprobst, Frederik, Pagenstecher, Axel, Nist, Andrea, Mernberg, Marco, Schneider, André, Braun, Thomas, Borggrefe, Tilman, Savai, Rajkumar, Timofeev, Oleg, Stiewe, Thorsten
Formato: Artículo
Lenguaje:inglés
Publicado: Philipps-Universität Marburg 2022
Materias:
Orthotopic tumor
Adenovirus
Luciferase
Medizin
CRISPR
Lung cancer
Autochthonous mouse tumor
Medical sciences Medicine
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