IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model

IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model

In pancreatic ductal adenocarcinoma (PDAC), the infiltration of CD8+ cytotoxic T cells (CTLs) is an important factor in determining prognosis. The migration pattern and interaction behavior of intratumoral CTLs are pivotal to tumor rejection. NLRP3-dependent proinflammatory cytokines IL-1β and IL-18...

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Autoren: Nasiri, Elena, Student, Malte, Roth, Katrin, Siti Utami, Nadya, Huber, Magdalena, Buchholz, Malte, Gress, Thomas M., Bauer, Christian
Formato: Artigo
Idioma:inglés
Publicado: Philipps-Universität Marburg 2023
Schlagworte:
cytokines
live cell imaging
pausing phases/arrest coefficient
Medizin
fluorophore
T-cell plasticity
intravital two-photon microscopy animal models for intravital imaging
pancreatic carcinoma
tumor spheroid coculture model
T-cell migration
Medical sciences Medicine
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