The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...

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Autoren: Weber, Lisa Marie, Jia, Yulin, Stielow, Bastian, Gisselbrecht, Stephen S., Cao, Yinghua, Ren, Yanpeng, Rohner, Iris, King, Jessica, Rothman, Elisabeth, Fischer, Sabrina, Simon, Clara, Forné, Ignasi, Nist, Andrea, Stiewe, Thorsten, Bulyk, Martha L., Wang, Zhanxin, Liefke, Robert
Format: Artikel
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2023
Teme:
Medizin
Medical sciences Medicine
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