Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163highCD206high tumor‐associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally linked. Transcriptional profiling re...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Hammoud, Mohamad K., Dietze, Raimund, Pesek, Jelena, Finkernagel, Florian, Unger, Annika, Bieringer, Tim, Nist, Andrea, Stiewe, Thorsten, Bhagwat, Aditya M., Nockher, Wolfgang Andreas, Reinartz, Silke, Müller-Brüsselbach, Sabine, Graumann, Johannes, Müller, Rolf
Materialtyp: Artikel
Språk:engelska
Publicerad: Philipps-Universität Marburg 2022
Ämnen:
interferon
Medizin
arachidonic acid
ovarian cancer microenvironment
macrophage
STAT
lipid rafts
Medical sciences Medicine
Länkar:PDF-fulltext
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Internet

PDF-fulltext

Beståndsuppgifter i
Signum: urn:nbn:de:hebis:04-es2024-02204
Utgivningstid: 2024-01-09
Källa: Erstveröffentlichung: Hammoud MK, Dietze R, Pesek J, Finkernagel F, Unger A, Bieringer T, Nist A, Stiewe T, Bhagwat AM, Nockher WA, Reinartz S, Müller-Brüsselbach S, Graumann J, Müller R. Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures. Mol Oncol. 2022 Sep;16(17):3146-3166. doi: https://doi.org/10.1002/1878-0261.13221
Downloads: 35 (2024)
Lizenz: https://creativecommons.org/licenses/by/4.0
Länk till materialet: https://archiv.ub.uni-marburg.de/es/2024/0220
https://doi.org/10.1002/1878-0261.13221

Liknande verk