Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures
Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163highCD206high tumor‐associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally linked. Transcriptional profiling re...
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Principais autores: | , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | inglês |
Publicado em: |
Philipps-Universität Marburg
2022
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Acesso em linha: | Texto Completo em Formato PDF |
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Texto Completo em Formato PDFNúmero de Chamada: |
urn:nbn:de:hebis:04-es2024-02204 |
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Data de Publicação: |
2024-01-09 |
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Erstveröffentlichung: Hammoud MK, Dietze R, Pesek J, Finkernagel F, Unger A, Bieringer T, Nist A, Stiewe T, Bhagwat AM, Nockher WA, Reinartz S, Müller-Brüsselbach S, Graumann J, Müller R. Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures. Mol Oncol. 2022 Sep;16(17):3146-3166. doi: https://doi.org/10.1002/1878-0261.13221 |
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35 (2024) |
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https://creativecommons.org/licenses/by/4.0 |
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https://archiv.ub.uni-marburg.de/es/2024/0220 https://doi.org/10.1002/1878-0261.13221 |