Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163highCD206high tumor‐associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally linked. Transcriptional profiling re...

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Príomhchruthaitheoirí: Hammoud, Mohamad K., Dietze, Raimund, Pesek, Jelena, Finkernagel, Florian, Unger, Annika, Bieringer, Tim, Nist, Andrea, Stiewe, Thorsten, Bhagwat, Aditya M., Nockher, Wolfgang Andreas, Reinartz, Silke, Müller-Brüsselbach, Sabine, Graumann, Johannes, Müller, Rolf
Formáid: Alt
Teanga:Béarla
Foilsithe / Cruthaithe: Philipps-Universität Marburg 2022
Ábhair:
interferon
Medizin
arachidonic acid
ovarian cancer microenvironment
macrophage
STAT
lipid rafts
Medical sciences Medicine
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Gairmuimhir: urn:nbn:de:hebis:04-es2024-02204
Dáta a fhoilsithe: 2024-01-09
Foinse: Erstveröffentlichung: Hammoud MK, Dietze R, Pesek J, Finkernagel F, Unger A, Bieringer T, Nist A, Stiewe T, Bhagwat AM, Nockher WA, Reinartz S, Müller-Brüsselbach S, Graumann J, Müller R. Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures. Mol Oncol. 2022 Sep;16(17):3146-3166. doi: https://doi.org/10.1002/1878-0261.13221
Downloads: 35 (2024)
Lizenz: https://creativecommons.org/licenses/by/4.0
URL Rochtana: https://archiv.ub.uni-marburg.de/es/2024/0220
https://doi.org/10.1002/1878-0261.13221

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