Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Hammoud, Mohamad K.; Dietze, Raimund; Pesek, Jelena; Finkernagel, Florian; Unger, Annika; Bieringer, Tim; Nist, Andrea; Stiewe, Thorsten; Bhagwat, Aditya M.; Nockher, Wolfgang Andreas; Reinartz, Silke; Müller-Brüsselbach, Sabine; Graumann, Johannes; Müller, Rolf

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163highCD206high tumor‐associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally linked. Transcriptional profiling re...

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Autoren:	Hammoud, Mohamad K., Dietze, Raimund, Pesek, Jelena, Finkernagel, Florian, Unger, Annika, Bieringer, Tim, Nist, Andrea, Stiewe, Thorsten, Bhagwat, Aditya M., Nockher, Wolfgang Andreas, Reinartz, Silke, Müller-Brüsselbach, Sabine, Graumann, Johannes, Müller, Rolf
格式:	Artikel
語言:	英语
出版:	Philipps-Universität Marburg 2022
主題:	interferon Medizin arachidonic acid ovarian cancer microenvironment macrophage STAT lipid rafts Medical sciences Medicine
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Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

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