Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones

Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones

Legionella pneumophila (L.p.) is a bacterial pathogen which is a common causative agent of pneumonia. In humans, it infects alveolar macrophages and transfers hundreds of virulence factors that interfere with cellular signalling pathways and the transcriptomic landscape to sustain its own replicatio...

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Autori principali: Herbel, Stefanie M., Moyon, Lambert, Christ, Marvin, Elsayed, Eslam M., Caffrey, Brian E., Malmsheimer, Silke, Grin, Iwan, Hoffmann, Kerstin, Surmann, Kristin, Blankenburg, Sascha, Jung, Anna Lena, Herkt, Christina E., Borsò, Marco, Bozdag, Beyza, Imhof, Axel, Becker, Anke, Wagner, Samuel, Bange, Gert, Völker, Uwe, Bertrams, Wilhelm, Marsico, Annalisa, Schmeck, Bernd
Natura: Articolo
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2022
Soggetti:
macrophage
Smh1
histone-deacetylase
Legionella pneumophila
Medizin
Infection
Medical sciences Medicine
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