The iron–sulfur cluster assembly (ISC) protein Iba57 executes a tetrahydrofolate-independent function in mitochondrial [4Fe–4S] protein maturation

The iron–sulfur cluster assembly (ISC) protein Iba57 executes a tetrahydrofolate-independent function in mitochondrial [4Fe–4S] protein maturation

Mitochondria harbor the bacteria-inherited iron–sulfur cluster assembly (ISC) machinery to generate [2Fe–2S; iron–sulfur (Fe–S)] and [4Fe–4S] proteins. In yeast, assembly of [4Fe–4S] proteins specifically involves the ISC proteins Isa1, Isa2, Iba57, Bol3, and Nfu1. Functional defects in their human...

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Bibliografiska uppgifter
Huvudupphovsmän: Mühlenhoff, Ulrich, Weiler, Benjamin Dennis, Nadler, Franziska, Millar, Robert, Kothe, Isabell, Freibert, Sven-Andreas, Altegoer, Florian, Bange, Gert, Lill, Roland
Materialtyp: Artikel
Språk:engelska
Publicerad: Philipps-Universität Marburg 2022
Ämnen:
crystallography
mitochondria
Medizin
mitochondrial disease
iron–sulfur protein
iron–sulfur cluster assembly
folate
Medical sciences Medicine
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