Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II

Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II

Hypoxia stabilizes the transcription factor HIF-1α, which promotes the transcription of many genes essential to adapt to reduced oxygen levels. Besides proline hydroxylation, expression of HIF-1α is also regulated by a range of other posttranslational modifications including phosphorylation by cAMP-...

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Bibliographic Details
Main Authors: Seaayfan, Elie, Nasrah, Sadiq, Quell, Lea, Radi, Aline, Kleim, Maja, Schermuly, Ralph T., Weber, Stefanie, Laghmani, Kamel, Kömhoff, Martin
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
hypoxia
HIF-1α
MAGED2
Medizin
PKA type II
Bartter
GalphaS
Medical sciences Medicine
Online Access:PDF Full Text
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