The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate...

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Main Authors: Hedderich, Janik B., Persechino, Margherita, Becker, Katharina, Heydenreich, Franziska M., Gutermuth, Torben, Bouvier, Michel, Bünemann, Moritz, Kolb, Peter
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
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Call Number: urn:nbn:de:hebis:04-es2023-01309
Publication Date: 2023-09-04
Source: Erstveröffentlichung: Hedderich, J.B., Persechino, M., Becker, K. et al. The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites. Nat Commun 13, 2567 (2022). https://doi.org/10.1038/s41467-022-29609-6
Downloads: 12 (2024), 29 (2023)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0130
https://doi.org/10.1038/s41467-022-29609-6