The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate...
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Sprache: | Englisch |
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Philipps-Universität Marburg
2022
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urn:nbn:de:hebis:04-es2023-01309 |
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Publikationsdatum: |
2023-09-04 |
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Erstveröffentlichung: Hedderich, J.B., Persechino, M., Becker, K. et al. The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites. Nat Commun 13, 2567 (2022). https://doi.org/10.1038/s41467-022-29609-6 |
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https://creativecommons.org/licenses/by/4.0 |
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https://archiv.ub.uni-marburg.de/es/2023/0130 https://doi.org/10.1038/s41467-022-29609-6 |