The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate...

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Autori principali: Hedderich, Janik B., Persechino, Margherita, Becker, Katharina, Heydenreich, Franziska M., Gutermuth, Torben, Bouvier, Michel, Bünemann, Moritz, Kolb, Peter
Natura: Articolo
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2022
Soggetti:
Pharmakologie, Therapeutik
Pharmacology & therapeutics, prescription drugs
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