The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate...

Full description

Bibliographic Details

Main Authors:	Hedderich, Janik B., Persechino, Margherita, Becker, Katharina, Heydenreich, Franziska M., Gutermuth, Torben, Bouvier, Michel, Bünemann, Moritz, Kolb, Peter
Format:	Article
Language:	English
Published:	Philipps-Universität Marburg 2022
Subjects:	Pharmakologie, Therapeutik Pharmacology & therapeutics, prescription drugs
Online Access:	PDF Full Text
Tags:	Add Tag No Tags, Be the first to tag this record!