The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate...

Full description

Saved in:
Bibliographic Details
Main Authors: Hedderich, Janik B., Persechino, Margherita, Becker, Katharina, Heydenreich, Franziska M., Gutermuth, Torben, Bouvier, Michel, Bünemann, Moritz, Kolb, Peter
Format: Article
Published: Philipps-Universität Marburg 2022
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!