Partial p53 reactivation is sufficient to induce cancer regression

Partial p53 reactivation is sufficient to induce cancer regression

Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor cells often become addicted to the absence of p53 providing a rationale...

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Bibliographic Details
Main Authors: Klimovich, Boris, Meyer, Laura, Merle, Nastasja, Neumann, Michelle, König, Alexander M., Ananikidis, Nikolaos, Keber, Corinna U., Elmshäuser, Sabrina, Tomofeev, Oleg, Stiewe, Thorsten
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
p53
Mouse models
Medizin
Molecular therapy
p53 reactivation
Lymphoma
Leukemia
Tumor suppressor gene
Medical sciences Medicine
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Summary:Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor cells often become addicted to the absence of p53 providing a rationale for developing p53 reactivating compounds to treat cancer patients. Unfortunately, many of the compounds that are currently undergoing preclinical and clinical testing fail to fully reactivate mutant p53 proteins, raising the crucial question: how much p53 activity is needed to elicit a therapeutic effect?
Item Description:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
DOI:10.1186/s13046-022-02269-6

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