Partial p53 reactivation is sufficient to induce cancer regression

Partial p53 reactivation is sufficient to induce cancer regression

Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor cells often become addicted to the absence of p53 providing a rationale...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Klimovich, Boris, Meyer, Laura, Merle, Nastasja, Neumann, Michelle, König, Alexander M., Ananikidis, Nikolaos, Keber, Corinna U., Elmshäuser, Sabrina, Tomofeev, Oleg, Stiewe, Thorsten
Aineistotyyppi: Artikkeli
Kieli:englanti
Julkaistu: Philipps-Universität Marburg 2022
Aiheet:
p53
Mouse models
Medizin
Molecular therapy
p53 reactivation
Lymphoma
Leukemia
Tumor suppressor gene
Medical sciences Medicine
Linkit:PDF-kokoteksti
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