Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

Otte, Katharina; Zhao, Kai; Braun, Madita; Neubauer, Andreas; Raifer, Hartmann; Helmprobst, Frederik; Barrera, Felipe Ovalle; Nimsky, Christopher; Bartsch, Jörg W.; Rusch, Tillmann

Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

Current standard adjuvant therapy of glioblastoma multiforme (GBM) using temozolomide (TMZ) frequently fails due to therapy resistance. Thus, novel therapeutic approaches are highly demanded. We tested the therapeutic efficacy of the second-generation XPO1 inhibitor Eltanexor using assays for cell v...

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Ngā kaituhi matua:	Otte, Katharina, Zhao, Kai, Braun, Madita, Neubauer, Andreas, Raifer, Hartmann, Helmprobst, Frederik, Barrera, Felipe Ovalle, Nimsky, Christopher, Bartsch, Jörg W., Rusch, Tillmann
Hōputu:	Tuhinga
Reo:	Ingarihi
I whakaputaina:	Philipps-Universität Marburg 2022
Ngā marau:	radiosensitivity XPO1 Eltanexor SINE temozolomide Medizin GBM Medical sciences Medicine
Urunga tuihono:	Kuputuhi katoa PDF
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Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

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