Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

Current standard adjuvant therapy of glioblastoma multiforme (GBM) using temozolomide (TMZ) frequently fails due to therapy resistance. Thus, novel therapeutic approaches are highly demanded. We tested the therapeutic efficacy of the second-generation XPO1 inhibitor Eltanexor using assays for cell v...

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Main Authors: Otte, Katharina, Zhao, Kai, Braun, Madita, Neubauer, Andreas, Raifer, Hartmann, Helmprobst, Frederik, Barrera, Felipe Ovalle, Nimsky, Christopher, Bartsch, Jörg W., Rusch, Tillmann
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
radiosensitivity
XPO1
Eltanexor
SINE
temozolomide
Medizin
GBM
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2023-00588
Publication Date: 2023-05-16
Source: Erstveröffentlichung: Otte, K.; Zhao, K.; Braun, M.; Neubauer, A.; Raifer, H.; Helmprobst, F.; Barrera, F.O.; Nimsky, C.; Bartsch, J.W.; Rusch, T. Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide. Biomedicines 2022, 10, 2145. https://doi.org/10.3390/biomedicines10092145
Downloads: 21 (2024), 44 (2023)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0058
https://doi.org/10.3390/biomedicines10092145

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