Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

Current standard adjuvant therapy of glioblastoma multiforme (GBM) using temozolomide (TMZ) frequently fails due to therapy resistance. Thus, novel therapeutic approaches are highly demanded. We tested the therapeutic efficacy of the second-generation XPO1 inhibitor Eltanexor using assays for cell v...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Otte, Katharina, Zhao, Kai, Braun, Madita, Neubauer, Andreas, Raifer, Hartmann, Helmprobst, Frederik, Barrera, Felipe Ovalle, Nimsky, Christopher, Bartsch, Jörg W., Rusch, Tillmann
Fformat: Erthygl
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2022
Pynciau:
radiosensitivity
XPO1
Eltanexor
SINE
temozolomide
Medizin
GBM
Medical sciences Medicine
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