Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines

Subtil, Florentine S. B.; Gröbner, Carolin; Recknagel, Niklas; Parplys, Ann Christin; Kohl, Sibylla; Arenz, Andrea; Eberle, Fabian; Dikomey, Ekkehard; Engenhart-Cabillic, Rita; Schötz, Ulrike

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines

Head and neck cancers (HNSCCs), especially in the advanced stages, are predominantly treated by radiochemotherapy, including cisplatin. The cure rates are clearly higher for HPV-positive HNSCCs when compared to HPV-negative HNSCCs. For both entities, this treatment is accompanied by serious adverse...

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Główni autorzy:	Subtil, Florentine S. B., Gröbner, Carolin, Recknagel, Niklas, Parplys, Ann Christin, Kohl, Sibylla, Arenz, Andrea, Eberle, Fabian, Dikomey, Ekkehard, Engenhart-Cabillic, Rita, Schötz, Ulrike
Format:	Artykuł
Język:	angielski
Wydane:	Philipps-Universität Marburg 2023
Hasła przedmiotowe:	Medizin HPV NVP-BEZ235 clonogenic survival cisplatin HNSCC radiosensitization irradiation Medical sciences Medicine
Dostęp online:	PDF pełnotekstowe
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Publikationen im Open Access gefördert durch die UB

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines

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