Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines

Head and neck cancers (HNSCCs), especially in the advanced stages, are predominantly treated by radiochemotherapy, including cisplatin. The cure rates are clearly higher for HPV-positive HNSCCs when compared to HPV-negative HNSCCs. For both entities, this treatment is accompanied by serious adverse...

Fuld beskrivelse

Gespeichert in:
Bibliografiske detaljer
Autoren: Subtil, Florentine S. B., Gröbner, Carolin, Recknagel, Niklas, Parplys, Ann Christin, Kohl, Sibylla, Arenz, Andrea, Eberle, Fabian, Dikomey, Ekkehard, Engenhart-Cabillic, Rita, Schötz, Ulrike
Format: Artikel
Sprog:engelsk
Udgivet: Philipps-Universität Marburg 2023
Fag:
Medizin
HPV
NVP-BEZ235
clonogenic survival
cisplatin
HNSCC
radiosensitization
irradiation
Medical sciences Medicine
Online adgang:PDF-Volltext
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
Publikationen im Open Access gefördert durch die UB

Lignende værker