Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

Amin, Muhammad Umair; Ali, Sajid; Alie, Muhammad Yasir; Fuhrmann, Dominik C.; Tarik, Imran; Seitz, Benjamin S.; Preis, Eduard; Büßler, Jana; Brüne, Bernhard; Bakowsky, Udo

Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

Hypoxia, an oxygen-deprived condition of the tumor, is one of the major reasons for resistance to chemotherapy. Carbonic anhydrases are generally involved in pH homeostasis in normal conditions, but in solid tumors having a strong relation with hypoxia, the car...

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Autoren:	Amin, Muhammad Umair, Ali, Sajid, Alie, Muhammad Yasir, Fuhrmann, Dominik C., Tarik, Imran, Seitz, Benjamin S., Preis, Eduard, Büßler, Jana, Brüne, Bernhard, Bakowsky, Udo
Formato:	Artigo
Idioma:	inglés
Publicado:	Philipps-Universität Marburg 2023
Schlagworte:	Pharmakologie, Therapeutik Hypoxia mesoporous silica nanoparticles liposomes co-delivery CA-IX enzyme inhibition Pharmacology & therapeutics, prescription drugs
Acceso en liña:	Texto completo PDF
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Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

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