Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

Hypoxia, an oxygen-deprived condition of the tumor, is one of the major reasons for resistance to chemotherapy. Carbonic anhydrases are generally involved in pH homeostasis in normal conditions, but in solid tumors having a strong relation with hypoxia, the car...

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Detalhes bibliográficos
Autoren: Amin, Muhammad Umair, Ali, Sajid, Alie, Muhammad Yasir, Fuhrmann, Dominik C., Tarik, Imran, Seitz, Benjamin S., Preis, Eduard, Büßler, Jana, Brüne, Bernhard, Bakowsky, Udo
Formato: Artigo
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2023
Assuntos:
Pharmakologie, Therapeutik
Hypoxia
mesoporous silica nanoparticles
liposomes
co-delivery
CA-IX enzyme inhibition
Pharmacology & therapeutics, prescription drugs
Acesso em linha:Texto integral em PDF
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