Inflammation and Wasting of Skeletal Muscles in Kras-p53-Mutant Mice with Intraepithelial Neoplasia and Pancreatic Cancer — When Does Cachexia Start?

Inflammation and Wasting of Skeletal Muscles in Kras-p53-Mutant Mice with Intraepithelial Neoplasia and Pancreatic Cancer — When Does Cachexia Start?

Skeletal muscle wasting critically impairs the survival and quality of life in patients with pancreatic ductal adenocarcinoma (PDAC). To identify the local factors initiating muscle wasting, we studied inflammation, fiber cross-sectional area (CSA), composition, amino acid metabolism and capillar...

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Detalhes bibliográficos
Principais autores: Hildebrand, Wulf, Keck, Jan, Schmich, Simon, Bonaterra, Gabriel A., Wilhelm, Beate, Schwarzbach, Hans, Eva, Anna, Bertoune, Mirjam, Slater, Emily P., Fendrich, Volker, Kinscherf, Ralf
Formato: Artigo
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2023
Assuntos:
gastrointestinal cancer
cancer cachexia
muscle atrophy
cytokines
sarcopenia
Medizin
weight loss
Medical sciences Medicine
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