Robustness of the Autophagy Pathway to Somatic Copy Number Losses

Robustness of the Autophagy Pathway to Somatic Copy Number Losses

Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore mark a metabolically vulnerable cancer state and ope...

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Xehetasun bibliografikoak
Egile Nagusiak: Polo, Pierfrancesco, Gremke, Niklas, Stiewe, Thorsten, Wanzel, Michael
Formatua: Artikulua
Hizkuntza:ingelesa
Argitaratua: Philipps-Universität Marburg 2023
Gaiak:
aerobic glycolysis
cancer metabolism
somatic copy number alterations (SCNAs)
Medizin
metabolic cancer ther
copy number loss
haploinsufficiency
autophagy
Medical sciences Medicine
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