Robustness of the Autophagy Pathway to Somatic Copy Number Losses

Robustness of the Autophagy Pathway to Somatic Copy Number Losses

Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore mark a metabolically vulnerable cancer state and ope...

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Autors principals: Polo, Pierfrancesco, Gremke, Niklas, Stiewe, Thorsten, Wanzel, Michael
Format: Article
Idioma:anglès
Publicat: Philipps-Universität Marburg 2023
Matèries:
aerobic glycolysis
cancer metabolism
somatic copy number alterations (SCNAs)
Medizin
metabolic cancer ther
copy number loss
haploinsufficiency
autophagy
Medical sciences Medicine
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