TLR8 is activated by 5ʹ-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway

TLR8 is activated by 5ʹ-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway

The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5ʹ-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor 8 (TLR8)...

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Autoren: Köllisch, Gabriele, Venegas Solis, Francisco, Obermann, Hannah-Lena, Eckert, Jeannine, Bauer, Stefan, Vierbuchen, Tim
格式: Artikel
語言:英语
出版: Philipps-Universität Marburg 2023
主題:
Medizin
Medical sciences Medicine
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索引號: urn:nbn:de:hebis:04-es2023-00026
Publikationsdatum: 2023-03-06
Quelle: Erstveröffentlichung: Köllisch et al., 2022, Cell Reports 39, 110691. https://doi.org/10.1016/j.celrep.2022.110691
Downloads: 26 (2024), 38 (2023)
Lizenz: https://creativecommons.org/licenses/by-nc-sa/4.0
Zugangs-URL: https://archiv.ub.uni-marburg.de/es/2023/0002
https://doi.org/10.1016/j.celrep.2022.110691

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