TLR8 is activated by 5ʹ-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway
The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5ʹ-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor 8 (TLR8)...
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Huvudupphovsmän: | , , , , , |
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Materialtyp: | Artikel |
Språk: | engelska |
Publicerad: |
Philipps-Universität Marburg
2023
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Länkar: | PDF-fulltext |
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Internet
PDF-fulltextSignum: |
urn:nbn:de:hebis:04-es2023-00026 |
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Utgivningstid: |
2023-03-06 |
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Erstveröffentlichung: Köllisch et al., 2022, Cell Reports 39, 110691. https://doi.org/10.1016/j.celrep.2022.110691 |
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26 (2024), 38 (2023) |
Lizenz: |
https://creativecommons.org/licenses/by-nc-sa/4.0 |
Länk till materialet: |
https://archiv.ub.uni-marburg.de/es/2023/0002 https://doi.org/10.1016/j.celrep.2022.110691 |