TLR8 is activated by 5ʹ-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway
The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5ʹ-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor 8 (TLR8)...
Sábháilte in:
Príomhchruthaitheoirí: | , , , , , |
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Formáid: | Alt |
Teanga: | Béarla |
Foilsithe / Cruthaithe: |
Philipps-Universität Marburg
2023
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Ábhair: | |
Rochtain ar líne: | An téacs iomlán mar PDF |
Clibeanna: |
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Ar líne
An téacs iomlán mar PDFGairmuimhir: |
urn:nbn:de:hebis:04-es2023-00026 |
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Dáta a fhoilsithe: |
2023-03-06 |
Foinse: |
Erstveröffentlichung: Köllisch et al., 2022, Cell Reports 39, 110691. https://doi.org/10.1016/j.celrep.2022.110691 |
Downloads: |
23 (2024), 38 (2023) |
Lizenz: |
https://creativecommons.org/licenses/by-nc-sa/4.0 |
URL Rochtana: |
https://archiv.ub.uni-marburg.de/es/2023/0002 https://doi.org/10.1016/j.celrep.2022.110691 |