TLR8 is activated by 5ʹ-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway

TLR8 is activated by 5ʹ-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway

The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5ʹ-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor 8 (TLR8)...

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Autores principales: Köllisch, Gabriele, Venegas Solis, Francisco, Obermann, Hannah-Lena, Eckert, Jeannine, Bauer, Stefan, Vierbuchen, Tim
Formato: Artículo
Lenguaje:inglés
Publicado: Philipps-Universität Marburg 2023
Materias:
Medizin
Medical sciences Medicine
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