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The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA
Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using 437 different small interfering RNAs (siRNA...
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| Autoren: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | inglês |
| Publicado em: |
Philipps-Universität Marburg
2022
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| Assuntos: | |
| Acesso em linha: | Texto integral em PDF |
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Internet
Texto integral em PDF| Área/Cota: |
urn:nbn:de:hebis:04-es2022-01719 |
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| Publikationsdatum: |
2022-11-23 |
| Fonte: |
Erstveröffentlichung: Rehberger, Miriam; Schäfer, Jonas A.; Krampitz, Anna-Maria; Bretz, Anne Catherine; Jost, Lukas; Haferlach, Torsten; Stiewe, Thorsten; Neubauer, Andreas. The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA. HemaSphere: May 2022 - Volume 6 - Issue 5 - p e0708 https://doi.org/10.1097/HS9.0000000000000708 |
| Downloads: |
31 (2024), 55 (2023), 3 (2022) |
| Lizenz: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Zugangs-URL: |
https://archiv.ub.uni-marburg.de/es/2022/0171 https://doi.org/10.1097/HS9.0000000000000708 |