The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using 437 different small interfering RNAs (siRNA...

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Hoofdauteurs: Rehberger, Miriam, Schäfer, Jonas A., Krampitz, Anna-Maria, Bretz, Anne Catherine, Jost, Lukas, Haferlach, Torsten, Stiewe, Thorsten, Neubauer, Andreas
Formaat: Artikel
Taal:Engels
Gepubliceerd in: Philipps-Universität Marburg 2022
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Plaatsingsnummer: urn:nbn:de:hebis:04-es2022-01719
Publicatiedatum: 2022-11-23
Bron: Erstveröffentlichung: Rehberger, Miriam; Schäfer, Jonas A.; Krampitz, Anna-Maria; Bretz, Anne Catherine; Jost, Lukas; Haferlach, Torsten; Stiewe, Thorsten; Neubauer, Andreas. The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA. HemaSphere: May 2022 - Volume 6 - Issue 5 - p e0708 https://doi.org/10.1097/HS9.0000000000000708
Downloads: 31 (2024), 55 (2023), 3 (2022)
Lizenz: https://creativecommons.org/licenses/by-nc-nd/4.0/
URL naar item: https://archiv.ub.uni-marburg.de/es/2022/0171
https://doi.org/10.1097/HS9.0000000000000708