The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using 437 different small interfering RNAs (siRNA...

Descrición completa

Gardado en:
Detalles Bibliográficos
Autoren: Rehberger, Miriam, Schäfer, Jonas A., Krampitz, Anna-Maria, Bretz, Anne Catherine, Jost, Lukas, Haferlach, Torsten, Stiewe, Thorsten, Neubauer, Andreas
Formato: Artigo
Idioma:inglés
Publicado: Philipps-Universität Marburg 2022
Schlagworte:
Medizin
Medical sciences Medicine
Acceso en liña:Texto completo PDF
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Internet

Texto completo PDF

Detalle de Existencias desde
Número de Clasificación: urn:nbn:de:hebis:04-es2022-01719
Data de Publicación: 2022-11-23
Fonte: Erstveröffentlichung: Rehberger, Miriam; Schäfer, Jonas A.; Krampitz, Anna-Maria; Bretz, Anne Catherine; Jost, Lukas; Haferlach, Torsten; Stiewe, Thorsten; Neubauer, Andreas. The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA. HemaSphere: May 2022 - Volume 6 - Issue 5 - p e0708 https://doi.org/10.1097/HS9.0000000000000708
Downloads: 31 (2024), 55 (2023), 3 (2022)
Lizenz: https://creativecommons.org/licenses/by-nc-nd/4.0/
URL de acceso: https://archiv.ub.uni-marburg.de/es/2022/0171
https://doi.org/10.1097/HS9.0000000000000708

Títulos similares