The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using 437 different small interfering RNAs (siRNA...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Rehberger, Miriam, Schäfer, Jonas A., Krampitz, Anna-Maria, Bretz, Anne Catherine, Jost, Lukas, Haferlach, Torsten, Stiewe, Thorsten, Neubauer, Andreas
Materialtyp: Artikel
Språk:engelska
Publicerad: Philipps-Universität Marburg 2022
Ämnen:
Medizin
Medical sciences Medicine
Länkar:PDF-fulltext
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!
Publikationen im Open Access gefördert durch die UB

Liknande verk