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The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA
Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using 437 different small interfering RNAs (siRNA...
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| Autori principali: | , , , , , , , |
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| Natura: | Articolo |
| Lingua: | inglese |
| Pubblicazione: |
Philipps-Universität Marburg
2022
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| Soggetti: | |
| Accesso online: | PDF Full Text |
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Publikationen im Open Access gefördert durch die UB