Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs

Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs

Humans can be infected by zoonotic avian, pandemic and seasonal influenza A viruses (IAVs), which differ by receptor specificity and conformational stability of their envelope glycoprotein hemagglutinin (HA). It was shown that receptor specificity of the HA determines the tropism of IAVs to human...

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Détails bibliographiques
Auteurs principaux: Dorna, Jens, Kaufmann, Andreas, Bockmann, Viktoria, Raifer, Hartmann, West, Johanna, Matrosovich, Mikhail, Bauer, Stefan
Format: Article
Langue:allemand
Publié: Philipps-Universität Marburg 2022
Sujets:
Medizin
influenza
primary immune cells
tropism
hemagglutinin
receptor specificity
Medical sciences Medicine
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