Toward Novel [18F]Fluorine-labeled Radiotracers for the Imaging of α-Synuclein Fibrils

Toward Novel [18F]Fluorine-labeled Radiotracers for the Imaging of α-Synuclein Fibrils

The accumulation of α-synuclein aggregates (α-syn) in the human brain is an occurrence common to all α-synucleinopathies. Non-invasive detection of these aggregates in a living brain with a target-specific radiotracer is not yet possible. We have recently discovered that the inclusion of a methylene...

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Bibliographic Details
Main Authors: Uzuegbunam, Bright C., Li, Junhao, Paslawsk, Wojciech, Weber, Wolfgang, Svenningsson, Per, Ågren, Hans, Yousefi, Behrooz Hooshyar
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
PET tracer development
α-synuclein aggregates
disaryl
Medizin
positron emission tomography (PET)
ruthenium-mediated deoxyfluorination
α-synucleinopathies
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2022-01463
Publication Date: 2022-08-31
Source: Erstveröffentlichung: Uzuegbunam BC, Li J, Paslawski W, Weber W, Svenningsson P, Ågren H and Yousefi BH (2022
Downloads: 52 (2024), 34 (2023), 2 (2022)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2022/0146
https://doi.org/10.3389/fnagi.2022.830704

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