Sökresultat - Klebe, Gerhard (Prof. Dr.)

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  1. 1
    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri

    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri av Gárdonyi, Marina

    Publicerad 2021
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  2. 2
    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase av Sandner, Anna Sophie

    Publicerad 2022
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  3. 3
    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the... av Badran, Mohammed

    Publicerad 2021
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  4. 4
    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase

    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase av Nguyen, Andreas

    Publicerad 2020
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  5. 5
    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A

    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A av Oebbeke, Matthias

    Publicerad 2021
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  6. 6
    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme av Nguyen, Dzung

    Publicerad 2020
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  7. 7
    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II av Glöckner, Steffen

    Publicerad 2020
    Övriga upphovsmän: “…Klebe, Gerhard Prof. Dr.…”
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  8. 8
    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. av Hassaan, Engi

    Publicerad 2019
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  9. 9
    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag zur Darstellung von Inhibitoren der Aldose-Reduktase und Carboanhydrase II

    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z... av Ngo, Trong Khang

    Publicerad 2020
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  10. 10
    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery av Petrick, Joy Kristin

    Publicerad 2019
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  11. 11
    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery av Münzker Lena

    Publicerad 2019
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  12. 12
    The Power of Fragments: FBLD approach to investigate protein structures

    The Power of Fragments: FBLD approach to investigate protein structures av Magari, Francesca

    Publicerad 2020
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  13. 13
    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana

    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana av Müller, Daniela

    Publicerad 2019
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr. rer. nat.)…”
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  14. 14
    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes

    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig... av Hüfner, Tobias

    Publicerad 2019
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  15. 15
    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin av Cramer, Jonathan

    Publicerad 2017
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  16. 16
    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography av Siefker, Christof

    Publicerad 2018
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  17. 17
    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques av Bertoletti, Nicole

    Publicerad 2017
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  18. 18
    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns

    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns av Terwesten, Felix

    Publicerad 2017
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  19. 19
    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A

    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A av Müller, Janis

    Publicerad 2017
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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  20. 20
    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study

    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study av Krimmer, Stefan Günter

    Publicerad 2017
    Övriga upphovsmän: “…Klebe, Gerhard (Prof. Dr.)…”
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