Rezultati - Klebe, Gerhard (Prof. Dr.)

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  1. 1
    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri

    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri od Gárdonyi, Marina

    Izdano 2021
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  2. 2
    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase od Sandner, Anna Sophie

    Izdano 2022
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  3. 3
    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the... od Badran, Mohammed

    Izdano 2021
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  4. 4
    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase

    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase od Nguyen, Andreas

    Izdano 2020
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  5. 5
    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A

    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A od Oebbeke, Matthias

    Izdano 2021
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  6. 6
    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme od Nguyen, Dzung

    Izdano 2020
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  7. 7
    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II od Glöckner, Steffen

    Izdano 2020
    Drugi avtorji: “...Klebe, Gerhard Prof. Dr....”
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  8. 8
    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. od Hassaan, Engi

    Izdano 2019
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  9. 9
    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag zur Darstellung von Inhibitoren der Aldose-Reduktase und Carboanhydrase II

    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z... od Ngo, Trong Khang

    Izdano 2020
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  10. 10
    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery od Petrick, Joy Kristin

    Izdano 2019
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  11. 11
    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery od Münzker Lena

    Izdano 2019
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  12. 12
    The Power of Fragments: FBLD approach to investigate protein structures

    The Power of Fragments: FBLD approach to investigate protein structures od Magari, Francesca

    Izdano 2020
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  13. 13
    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana

    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana od Müller, Daniela

    Izdano 2019
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr. rer. nat.)...”
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  14. 14
    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes

    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig... od Hüfner, Tobias

    Izdano 2019
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  15. 15
    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin od Cramer, Jonathan

    Izdano 2017
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  16. 16
    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography od Siefker, Christof

    Izdano 2018
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  17. 17
    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques od Bertoletti, Nicole

    Izdano 2017
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  18. 18
    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns

    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns od Terwesten, Felix

    Izdano 2017
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  19. 19
    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A

    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A od Müller, Janis

    Izdano 2017
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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  20. 20
    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study

    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study od Krimmer, Stefan Günter

    Izdano 2017
    Drugi avtorji: “...Klebe, Gerhard (Prof. Dr.)...”
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