Rezultaty - Klebe, Gerhard (Prof. Dr.)

Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri od Gárdonyi, Marina

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase od Sandner, Anna Sophie

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the... od Badran, Mohammed

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase od Nguyen, Andreas

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A od Oebbeke, Matthias

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme od Nguyen, Dzung

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II od Glöckner, Steffen

Kolejni autorzy: “…Klebe, Gerhard Prof. Dr.…”
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Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. od Hassaan, Engi

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z... od Ngo, Trong Khang

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery od Petrick, Joy Kristin

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery od Münzker Lena

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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The Power of Fragments: FBLD approach to investigate protein structures od Magari, Francesca

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana od Müller, Daniela

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr. rer. nat.)…”
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Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig... od Hüfner, Tobias

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin od Cramer, Jonathan

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography od Siefker, Christof

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques od Bertoletti, Nicole

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns od Terwesten, Felix

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A od Müller, Janis

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study od Krimmer, Stefan Günter

Kolejni autorzy: “…Klebe, Gerhard (Prof. Dr.)…”
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